THE Graft™ is a natural, porcine bone mineral matrix for bone reconstruction.
lt is produced by removal of all organic components from porcine bone.
Due to its native structure THE Graft™ likens the physical and chemical aspects of mineralized matrix of human bone.
When packed into a bone defect, THE Graft™ gradually resorbs and replaced with bone during the healing process. lt is available in cancellous granules packaged in vial and syringe. THE Graft™ is sterilized using gamma irradiation.
Unique proprietary manufacturing process removes very effectively potential immunogenic organic elements keeping the natural structure of the matrix. THE Graft™ quality and safety have been scientifically demonstrated with invitro, in-vivo studies, large case study reports and international randomized clinical research. Systematic review and meta-analysis are conducted on THE Graft™ worldwide.[1-2]
THE Graft™ has established its fame throughout the world, both scientifically and clinically, becoming a popular bone regeneration material.
[1] Alveolar ridge regeneration of damaged extraction sockets using deproteinized porcine versus bovine bone minerais: A randomized clinical trial. 100 patients Clin Implant Dent Relai Res 2018 Jul 27. Epub 2018 Jul 27.
[2] Randomized clinical trial of maxillary sinus grafting using deproteinized porcine and bovine bone minerai.
16 Patients clin implant dent relai Res. 2017; 19(11: 140-150)
THE Graft™ Syringe
BIOCOMPATIBILITY
BIOCOMPATIBILITY
«Getting closer to human bone»
The Graft™ is structurally similar to human tissue. It has high possible level of porosity combined with a natural interconnectivity.
Safe & Biocompatible
Ref : 01 – 02 – 06
The combination of porcine origin with the high level of purity enables predictable bone growth without risking an immunogenic reaction. The high biocompatibility of THE Graft™ has been confirmed by an in-vitro cell study. THE Graft™ therefore encourages cell adhesion to the same extent as the established natural DBBM and offers optimal conditions for vital cell growth.
THE Graft™ Syringe
PURITY
PURITY
Is THE Graft™ safe material ?
Ref: 01 – 06
Patented proprietary virus inactivation process technology.
Thanks to highly efficient patented manufacturing process, THE Graft™ is free from any organic components that might be potential causes of infection or immune reaction. This unique process preserves most of the physical properties of the native porcine osseous structure of THE Graft™.
A large surface area is a key requirement for graft materials, and not only results in a larger surface region available for osteoblast cells attachment but also facilitates the exchange of nutrients and waste products, it allows greater amounts of blood, proteins, and growth factors to be absorbed onto the scaffold.
THE Graft™ Syringe
HYDROPHILICITY
HYDROPHILICITY
Ref: 02 – 03
THE Graft™ consists of a unique inter-connection pore system that ensures an efficient fluid intake and permits the migration of cells. This pore system and high surface energy enhances the osteoconduction process.
The wettability of THE Graft™ turned out to be higher than compared existing xenografts, which suggests that THE Graft™ is relatively hydrophilic and can be easily wet by body fluids after implantation. Not only protein adsorption, but also the attachment, growth, and proliferation of various types of cells, including osteoblasts, have been reported to be significantly affected by the wettability of the material surface.
THE Graft™ SYRINGE
BIOCOMPATIBILITY
Biocomptability
«Getting closer to human bone»
Safe & Biocompatible
Ref : 01 – 02 – 06
The combination of porcine origin with the high level of purity enables predictable bone growth without risking an immunogenic reaction. The high biocompatibility of THE Graft™ has been confirmed by an in-vitro cell study. THE Graft™ therefore encourages cell adhesion to the same extent as the established natural DBBM and offers optimal conditions for vital cell growth.
THE Graft™ SYRINGE
PURITY
Purity
Is THE Graft™ safe material?
Ref: 01 – 06
Patented proprietary virus inactivation process technology.
Thanks to highly efficient patented manufacturing process, THE Graft™ is free from any organic components that might be potential causes of infection or immune reaction. This unique process preserves most of the physical properties of the native porcine osseous structure of THE Graft™.
A large surface area is a key requirement for graft materials, and not only results in a larger surface region available for osteoblast cells attachment but also facilitates the exchange of nutrients and waste products, it allows greater amounts of blood, proteins, and growth factors to be absorbed onto the scaffold.
THE Graft™ Syringe
Hydrophilicity
Hydrophilicity
Ref: 02 – 03
THE Graft™ consists of a unique inter-connection pore system that ensures an efficient fluid intake and permits the migration of cells. This pore system and high surface energy enhances the osteoconduction process.
The wettability of THE Graft™ turned out to be higher than compared existing xenografts, which suggests that THE Graft™ is relatively hydrophilic and can be easily wet by body fluids after implantation. Not only protein adsorption, but also the attachment, growth, and proliferation of various types of cells, including osteoblasts, have been reported to be significantly affected by the wettability of the material surface.
BIBLIOGRAPHY
THE Graft Immune bone ready to use in an easy-to-apply syringe.
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